![]() Aneuronal colon tissue was obtained from the distal resection margin (23 patients). We tested whether aneuronal (aganglionic) colon tissue from patients may be colonized by autologous ENS-derived cells.Ĭells were obtained and cryopreserved from 31 HSCR patients from the proximal resection margin of colon, and ENS cells were isolated using flow cytometry for the NC marker p75 (nine patients). Treatment is by distal bowel resection, but neural cell replacement may be an alternative. Hirschsprung disease (HSCR) is caused by failure of cells derived from the neural crest (NC) to colonize the distal bowel in early embryogenesis, resulting in absence of the enteric nervous system (ENS) and failure of intestinal transit postnatally.
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